| Yasunori Aizawa (Tokyo Institute of Technology) |
| Fri 28 Oct 2016, 12:00 - 12:30 |
| C.H Waddington Building, Seminar room 1.08, King's Building's |
If you have a question about this talk, please contact: Julie Fyffe (jfyffe)
This is the first of two 30min talks.
RIbosome profiling and mass spectrometry analyses reveal that more noncoding RNA regions in mammalian genomes can be translated than we previously expected. These putatively translatable open reading frames may encode proteins that are short (<100aa) and lack of known protein motifs. These proteins can be novel class of mammalian proteome, although their functionality have yet to be investigated. With our serendipitous finding of protein codingness of RNAs that were previously annotated as noncoding RNAs, we are now screening for functional proteins encoded in noncoding RNAs as well as 5’UTRs of mRNAs in mammals. In this seminar, I will introduce our up-to-date data and discuss mammalian proteome hidden in noncoding RNA genomic regions.