NADPH oxidases and cardiac stress responses

http://www.kcl.ac.uk/lsm/research/divisions/cardio/about/people/shaha.aspx

My scientific and academic background includes 25 years of experience in basic and translational research relevant to human diseases. Over the last 15 years, my group has had a major focus on oxidative stress, redox signalling and NADPH oxidases, with particular focus on their role in cardiovascular physiology and disease. We have contributed to the discovery and characterisation of NOX enzymes in the heart and endothelial cells, their role in cardiac hypertrophy, endothelial dysfunction and heart failure, and their involvement in signal transduction. Our recent work includes the development of novel gene-modified mouse models to study the in vivo roles of different NOX isoforms and analysis of their role in human cardiovascular disease. We have discovered novel roles of the NOX4 isoform that challenge the paradigm of ROS production as a detrimental feature of cardiovascular disease. We collaborate with many NOX scientists across the world, working on different areas such as stroke, lung disease, immune disease and cancer. Dr. Chatterjee’s grant application seeks to delineate the roles of endothelial versus non-endothelial NOX2 in signaling in an orthotropic mouse lung transplant model. For this work, the mice with endothelial specific deletion of NOX2 that were generated by my group would be very pivotal in understanding the roles of the endothelial versus non-endothelial cells. I would be happy to make them available for this project. As I have a broad perspective on translational research and the scientific, technical, and human resources required to accelerate the translation of new laboratory discoveries to the clinical arena, I am very excited with the possibilities of translating these findings into transplant medicine.