| various |
| Thu 25 Mar 2021, 09:30 - 10:30 |
| Online (Blackboard collaborate) |
If you have a question about this talk, please contact: Julie Fyffe (jfyffe)
Eric latorrecrespo (MRC/UoE Cross-Disciplinary Post-Doctoral Fellowship (XDF), MRC University Unit for Human Genetics)
Redefining Clonal Haematopoiesis of Indeterminate Potential through longitudinal data.
As we age, blood stem cells acquire genetic mutations that can disrupt the balanced production of blood cells forming large genetic clones. This premalignant stage is termed Clonal haematopoiesis of indeterminate potential (CHIP) and is associated with a 10-fold increase in the later onset of haematological malignancies such as myeloid leukaemia. In this talk I will explore why is it that some individuals with CHIP develop rapid clonal expansion and progression to malignancy, whereas others have clones that lay dormant for many years.