Prof Xiumei MO Keynote (Donghua University)

Electrospun Nanofibers and Nanoyarn for Tissue Engineering

Abstract:

Electrospinning nanofiber can biomimetic Extracellular Matrix and suitable for tissue scaffolding. In our group collagen-chitosan complex nanofibers have been fabricated for skin tissue engineering, collagen-chitosan-P(LLA-CL) nanofibers tube scaffold have been fabricated for blood vessel tissue engineering, silk-P(LLA-CL) nanofibers tube scaffold have been fabricated for nerve tissue engineering.

Electrospinning fabrication technique most commonly produces relatively 2D mats and the construction 3D structure nanofibers with higher porosity is still a major challenge. In our research, two methods were used to fabricate the 3D nanofiber scaffolds. A dynamic electrospinning method were developed to fabricate the nanoyarn scaffold. The nanoyarn scaffold contained 3D aligned microstructures with larger interconnected pores and higher porosity comparing with nanofiber scaffold. The nanoyarn scaffold have been successfully used for tendon tissue regeneration of rabbit. Gelatin/PLA nanofiberous 3D scaffold was fabricated by using combined electrospinning and freeze-drying methods. Thus obtained 3D nanofiber scaffold could promote cells growth and proliferation, it also been used for cartilage tissue engineering in rabbit.

Biography:

Dr. Xiumei MO is a professor of Biomaterials in Donghua University. She once had two years Postdoc experience in Kyoto University, three years research fellow experience in National University of Singapore, one year visiting professor experience in Aachen University of Applied Science and Technology. In Donghua University she was granted 28 projects related with nanofiber fabrication for different tissue regeneration and hydrogel as tissue adhesive. She has published more than 300 papers. ISI Web of Science showed that she ranking No.7 in the world on electrospun nanofiber publication. She got the Science Technical Invention Awards from Shanghai Municipality in 2008，Science and Technology Progress Awards from State Department of People’s Republic of China in 2009, Nature Science Awards from Shanghai Government in 2015. She is the committee members of China Biomaterials Society as well as Biomedical Engineering Society Biomaterials Branch.