Dr Velia Siciliano (Imperial College London) |
Thu 23 Nov 2017, 12:00 - 13:00 |
Michael Swann building, seminar room 7.20 King's Buildings |
If you have a question about this talk, please contact: Julie Fyffe (jfyffe)
Synthetic Biology aims at developing and applying engineering tools to sense and process endogenous information and to implement robust responses to intracellular conditions. Mammalian synthetic networks build on the conjugation of efforts to increase the number of DNA parts for genetic circuit assembly with minimal counteractive effect with the intracellular context, with the ability to design circuits that are activated when specific endogenous molecules are sensed within the cells. I will show our results on designing new genetic parts such as transcriptional activators and repressor in mammalian cells, and circuits based on RNA binding proteins as a new potential platform of gene delivery and genetic circuits regulation.